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Updated: Jul 4, 2026

Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
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在20年的时间内,胎儿酒精频谱障碍的脑容量超过20年

Adolf Pfefferbaum1,2, Edith V Sullivan2, Kilian M Pohl2

  • 1Center for Health Sciences, SRI International, Menlo Park, California.

JAMA network open
|November 17, 2023
PubMed
概括

患有胎儿酒精谱系障碍 (FASD) 的个人在中年时表现出持续的大脑体积缺陷,而不是加速衰老. 这项纵向研究强调了产前酒精暴露后持久的结构差异.

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses a challenge in...