黑素是否会降低非临床住院患者在需要时使用抗精神病药物或二氨酸的使用率? 一个多中心的回顾性队列研究
Paul Dobry1,2, Adina Poparad-Stezar3, Opal Bacon4
1Department of Pharmacy, Ascension St. John Hospital, Detroit, MI, USA.
Journal of integrative and complementary medicine
|November 17, 2023
概括
黑色素的使用可能会降低住院患者对二类药物 (BZD) 的需求,这可能有助于妄管理. 这项研究表明,黑激素是一种更安全的睡眠替代品,可以减少对BZD和抗精神病药物的依赖.
科学领域:
- 神经科学和药理学 神经科学和药理学
- 临床医学和老年病学
背景情况:
- 妄想是一种流行的神经精神综合征,缺乏FDA批准的治疗方法,需要有效的预防策略.
- 睡眠-清醒周期的干扰与痴呆症的发病有关,建议黑激素恢复昼夜节律的同步.
研究的目的:
- 调查黑素,二类药物 (BZDs),皮 (ZLP) 之间的关联,以及随后根据需要使用抗精神病药物和BZDs来治疗妄想症.
- 为了评估这些关联在非临界病的成人患者入院一般医院的楼层.
主要方法:
- 一项多中心的回顾性队列研究,从2012年8月到2018年12月,涉及225名非危急病的成年患者.
- 患者接受了黑激素或非黑激素睡眠辅助剂 (ZLP或BZD).
- 主要终点是患者在开始服用睡眠药物5天内需要预先服用 (PRN) 抗精神病药物或BZD的比例.
主要成果:
- 与BZD或ZLP相比,使用黑色素与PRN BZD管理的显著减少有关 (或2.78,95% CI 1.2-1.87对于BZD;或2.78,95% CI 1.25-6.17对于ZLP).
- 与BZD或ZLP相比,黑激素和PRN抗精神病药物使用之间没有发现显著的关联 (OR 1.09,95%CI 0.51-2.35对于BZD;OR 1.16,95%CI 0.56-2.4对于ZLP).
- 二次分析表明,65岁及以上的患者也有类似的趋势.
结论:
- 在住院的非危急病患者中使用黑色素与减少使用PRN类药物有关.
- 这些发现表明,黑激素可能是管理睡眠障碍的有价值的辅助剂,并可能通过减少对常用的精神药物药物的依赖来减少妄想的发生率或严重程度.
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