在重症监护室内的温度与急性呼吸困扰综合征患者的死亡率之间的关联
Yipeng Fang1,2,3, Yunfei Zhang4, Xianxi Huang5
1Laboratory of Molecular Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Therapeutic hypothermia and temperature management
|November 17, 2023
概括
身体温度影响急性呼吸困扰综合征 (ARDS) 的生存率. 过渡性轻度发烧可能有助于ARDS患者,但极端或长时间的高温会增加死亡风险.
科学领域:
- 关键护理医学 关键护理医学
- 生理学 生理学 生理学
- 临床研究 临床研究
背景情况:
- 在急性呼吸窘迫综合征 (ARDS) 中体温波动的预后意义尚未完全理解.
- 精确的温度监测对于管理重症患者至关重要.
研究的目的:
- 调查重症监护室 (ICU) 体温变化的临床价值,以预测ARDS成年患者的预后.
- 确定最大和最小体温与ARDS患者28天死亡率之间的关系.
主要方法:
- 从密集护理III (MIMIC-III) 数据库中对成年ARDS患者的回顾性分析.
- 根据最大 (温度_max) 和最小 (温度_min) ICU 温度对患者进行分组.
- 统计分析包括多项式回归,子组分析和逻辑回归来评估28天死亡率.
主要成果:
- 在ARDS患者的体温和28天死亡率之间观察到U形关系.
- 温度_max升高 (≥37.0°C) 与感染患者的死亡率降低有关 (或0.39-0.49).
- 低温 (<35.0°C) 和升温 (≥37.0°C) 与增加的死亡率有关;极端高温 (≥38.0°C) 在非感染患者中否定了益处.
结论:
- 过渡性,轻度高温症可能对ARDS患者有益,特别是那些感染的人.
- 低温是ARDS死亡的一个重要风险因素.
- 避免极度高温和持续高温对于改善ARDS患者的治疗结果至关重要.
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