用光生物调节作为预防化疗诱导口腔粘膜炎的有效方法的先决条件:系统性审查
Marwa Khalil1, Omar Hamadah1,2, Maher Saifo3,4
1Department of Oral Medicine, Faculty of Dentistry, Damascus University, Damascus, Syria.
Photobiomodulation, photomedicine, and laser surgery
|November 17, 2023
概括
光生物调制 (PBM) 在预防化疗诱导的口腔粘膜炎,一种痛苦的副作用方面表现有前途. 需要进一步的研究来优化PBM协议,以适应这一应用.
科学领域:
- 在瘤学瘤学.
- 生物医学工程 生物医学工程
背景情况:
- 化疗和放射治疗等癌症治疗会导致严重的副作用,包括口腔粘膜炎.
- 光生物调制 (PBM) 正在作为治疗相关毒性的预防措施进行研究.
- 口腔粘膜炎显著影响患者的生活质量和治疗坚持.
研究的目的:
- 系统地审查使用PBM预调剂在预防化疗诱导的口腔粘膜炎方面的有效性.
- 分析PBM用于预防口腔粘膜炎的现有临床试验.
- 为了确定最佳的PBM参数,以预防化疗诱导的口腔粘膜炎.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 在PubMed和Cochrane数据库中搜索相关的临床试验.
- 使用修订后的Cochrane偏差风险工具 (RoB 2.0) 评估偏差风险.
主要成果:
- 六项临床试验评估了PBM用于预防化疗诱导的口腔粘膜炎.
- 大多数研究使用了激光,其中一项研究比较了激光和发光二极管 (LED) (波长为630-830nm).
- 除了一项研究外,所有研究报告了PBM在预防口腔粘膜炎方面取得的积极结果.
结论:
- 当PBM应用于健康组织时,它在预防口腔粘膜炎方面似乎有效.
- 研究方案的变化阻碍了最佳PBM参数的确定.
- 建议进行精心设计的,受控的,盲目的研究,以建立精确的PBM协议,以预防口腔粘膜炎.
相关概念视频
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:28Chemotherapy-Induced Nausea and Vomiting: Neurokinin-1 Receptor Antagonists
169
Neurokinin 1 (NK1) receptors are distributed across the GI tract, vagal afferents, and key CNS regions including the central vomiting center and chemoreceptor trigger zone (CTZ) Chemotherapy agents stimulate enterochromaffin cells in the gastrointestinal (GI) tract to release large amounts of substance P (SP). SP is a neuropeptide released by specific sensory nerves in response to many different stressors, including those in the GI mucosa affected by chemotherapy. SP binds and activates...
169
01:27Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
215
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
215