不确定区多巴胺神经元编码的动机活力在寻找食物
Qiying Ye1, Jeremiah Nunez1, Xiaobing Zhang1
1Department of Psychology, Florida State University, Tallahassee, FL 32306, USA.
Science advances
|November 17, 2023
概括
不确定区多巴胺 (DA) 神经元对于激发饥饿期间寻找食物至关重要. 这些神经元投射到副腹腔丘脑 (PVT),驱动寻找食物的活力,并形成奖励记忆.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 恒温的食物寻找对于生存至关重要.
- 在饥饿驱动的寻找食物中,背后的激励活力的神经机制尚未得到充分理解.
研究的目的:
- 研究多巴胺 (DA) 神经元在不确定的区域 (ZI) 在编码在身体饥饿期间寻找食物的动机活力中的作用.
主要方法:
- 在ZI和腹膜区域 (VTA) 的DA神经元的切除.
- 化学基因操纵ZI DA神经元及其投射到对腹腔丘脑 (PVT).
- 对寻找食物,消费和上下文记忆的行为分析.
主要成果:
- 与VTA DA神经元切除不同的是,ZI DA神经元切除显著损害了禁食后寻找食物的能力.
- ZI DA神经元在食物接近时被激活,在消费时被抑制.
- ZI DA神经元操纵双向调节的食物频率,但不是食物大小.
- ZI DA神经元的激活促进了与食物相关的上下文记忆形成.
- 激活ZI DA对PVT的预测增强了食物寻找,并传递了积极价值信号.
结论:
- ZI DA神经元对于编码寻找食物的动机活力至关重要.
- ZI DA神经元,特别是它们对PVT的投射,在驱动饥饿驱动行为和奖励相关学习方面发挥着关键作用.
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