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实施新的计算方法来研究JCT和SC内部壁底膜生物力学和水力动力学

Alireza Karimi¹, Reza Razaghi², Siddharth Daniel D'costa²

¹Department of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, United States; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, United States.

Computer methods and programs in biomedicine

|November 17, 2023

概括

流体结构相互作用建模揭示了水性幽默在柔道管状组织 (JCT) 和施莱姆组织中不均的剪切应力.

科学领域:

眼睛的生物力学
流体动力学流体动力学
脊柱状网状网研究研究

背景情况:

状眼网 (TM),状眼管组织 (JCT) 和施莱姆通道 (SC) 通过控制水性幽默的外流来调节眼内压力 (IOP).
目前对这种外流通路内的生物力学和水力动力学的理解是有限的.
流体结构相互作用 (FSI) 建模为JCT和SC的生物力学特性提供了先进的见解.

研究的目的:

使用FSI估计JCT和SC的生物力学特性.
为了研究水性的流出途径中的水力动力学.
为了获得超出当前成像技术能力的洞察力.

主要方法:

从SBF-SEM图像创建了JCT和SC内部壁的3D有限元素 (FE) 模型.
一个逆代式FE算法计算了在0mmHg时的无负荷几何.
使用FSI来模拟从0到15mmHg的加压.

主要成果:

在JCT/SC综合体内,水性幽默剪切应力分布不均.
在SC内壁附近发生较高的剪切应力 (高达10Pa);在JCT附近发生较低的应力 (~4Pa).
巨型真空孔表现出差异性应变:没有I孔的约14%,与I孔的约9%.

结论:

在JCT/SC复合体中的不均的剪切应力分布可能解释了水性幽默外流中的选择性机制.
FSI建模为了解眼部生物力学提供了一个强大的工具.

关键词:

柔性状状组织新的计算模型.输出流的阻力输出流的阻力施莱姆的运河是施莱姆的运河.脊柱状的网状网状网状网状网状网.

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