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Tingxun Lu¹, Jie Zhang², Jenna M McCracken³

¹Division of Hematopathology, Duke University Medical Center, Durham, NC 27710, USA; Department of Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu Province 214122, China.

Cancer treatment reviews

|November 17, 2023

概括

膜细胞淋巴瘤 (MCL) 的理解已经进步,揭示了各种各样的亚型和治疗转变. 新疗法向耐药性,改善了复发性或耐药性MCL患者的治疗结果.

科学领域:

血液学血液学血液学
在瘤学瘤学.
遗传学是一个遗传学.

背景情况:

膜细胞淋巴瘤 (MCL) 具有显著的生物学和临床异质性.
预后和治疗受到包括免疫球蛋白基因突变状态,表观遗传学和Sox11表达等因素的影响.
像Cyclin D1-阴性MCL和CCND1/IGH FISH阴性MCL这样的亚型存在独特的挑战.

研究的目的:

提供一个全面的地幔细胞淋巴瘤 (MCL) 病理生物学,预后和不断发展的治疗策略的综合审查.
检查对疗法,特别是BTK抑制剂耐药性的遗传基础.
探索复发性或耐火性MCL的治疗选择.

主要方法:

关于MCL病理生物学,基因组学和临床表现的当前文献的综述.
对预后因素和分层治疗方法的分析.
对复发性/耐药性疾病的耐药性机制和新兴疗法的研究.

主要成果:

免疫化疗已经导致一些MCL患者的持续缓解.
BTK 抑制剂 (易布鲁丁尼布,阿卡拉布鲁丁尼布) 已经改变了MCL的治疗方法.
对BTK抑制剂的耐药性是一个重大挑战,需要新的治疗策略.

结论:

治疗MCL正在转向非化疗剂和向治疗.
克服BTK抑制剂耐药性的策略包括非共价抑制剂,BCL2抑制剂和CAR-T细胞疗法.
对新型药物和组合疗法的持续研究有望改善复发性/耐药性MCL的存活率.

关键词:

这是一种BTK抑制剂.地膜细胞淋巴瘤是什么新的经纪人新的经纪人预测预后预测预测电阻电阻电阻电阻电阻电阻

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