佩拉曼尼尔作为老年人的唯一附加治疗方法:从回顾性,多中心,观察性研究中对现实世界的数据进行子组分析
Angelo Pascarella1, Sara Gasparini1, Lucia Manzo1
1Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, Italy; Regional Epilepsy Centre, Great Metropolitan "Bianchi-Melacrino-Morelli Hospital", Reggio Calabria, Italy.
Journal of the neurological sciences
|November 17, 2023
概括
佩拉曼奈尔 (PER) 是有效的,并且可以作为老年患者的补充治疗. 这项实践研究表明,在这个人群中,发作显著减少,发作保持率高.
科学领域:
- 神经学 神经学
- 老年医学 老年医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于独特的生理变化和有限的具体数据,老年人的管理具有挑战性.
- 现有的抗发作药物 (ASM) 数据往往排除或低估了老年人群.
研究的目的:
- 为了评估perampanel (PER) 作为老年患者 (≥65岁) 的附加疗法的实际有效性和耐受性.
- 评估PER对该人口群的发作频率,治疗保留和不良事件的影响.
主要方法:
- 从一个更大的多中心研究中对65名老年患者 (平均年龄75.7岁) 进行了子组分析.
- 在12个月内收集了关于发作频率,不良事件和停止治疗的数据.
- 小组分析考虑了早期与晚期的PER治疗.
主要成果:
- 观察到高保留率:在3个月后90.5%,6个月后89.6%,12个月后79.4%.
- 在所有随访点,发作频率显著减少.
- 在一年内实现了89.7%的响应率 (≥50%的发作减少) 和72.4%的发作自由率.
- 常见的不良事件包括头和易怒;34.9%的患者经历了AEs.
结论:
- 佩拉曼奈尔 (PER) 是一种有效且耐受性良好的在现实临床环境下对老年人的补充治疗方法.
- 在老年人群中,PER代表了一种可行的治疗选择,用于治疗.
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