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通过设计PUFA功能化基于脂质的纳米载体来克服BBB/BBTB的生物障碍,用于质母细胞瘤向治疗

Tamara Zwain1, Jane Elizabeth Alder2, Suha Zwayen3

  • 1School of Pharmacy and Biomedical Sciences, University of Central Lancashire, Preston PR1 2HE, United Kingdom; Biomedical Evidence based Transdisciplinary (BEST) Health Research Institute, University of Central Lancashire, Preston PR1 2HE, United Kingdom.

Biomaterials advances
|November 17, 2023
PubMed
概括

新型纳米结构脂质载体 (NLCs) 携带多塞 (DTX) 被用玛-烯酸 (GLA) 和α-烯酸 (ALA) 功能化用于质母细胞瘤 (GB) 治疗. 这些NLC有效地穿越了血脑屏障 (BBB),并增强了向GB细胞的药物输送.

关键词:
阿尔法-烯酸 (ALA) 是一种血液-大脑屏障是什么?血脑瘤障碍物 血脑瘤障碍物 血脑瘤障碍物玛-烯酸 (GLA) 是一种玛-烯酸.质母细胞瘤 (glioblastoma) 是一个纳米结构的脂质载体多不和脂肪酸 (PUFA) 是一种多不和脂肪酸.表面功能化的功能化.有针对性的癌症治疗.

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