从一次性塑料杯中的光衰老微塑料上的环境持久的自由基诱导了与氧化应激相关的毒性
Hanling Cao1, Ping Ding2, Xintong Li2
1Technical Centre for Soil, Agriculture and Rural Ecology and Environment, Ministry of Ecology and Environment, Beijing 100012, China.
Journal of hazardous materials
|November 17, 2023
概括
环境持久性自由基 (EPFR) 在一次性杯子中老化的微塑料上形成. 这些EPFRs在线虫中引起毒性,与氧化应激有关,影响行为和繁殖.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 材料科学 材料科学 材料科学
背景情况:
- 微塑料 (MP) 是广泛存在的污染物,已知有毒作用.
- 大多数研究都使用未成年议员,缺乏环境现实主义.
- 环境持久性自由基 (EPFRs) 对光衰老的MPs的作用还没有得到充分研究.
研究的目的:
- 调查EPFR形成的照片老化一次性塑料杯MPs (DPC-MPs).
- 评估光老化DPC-MPs对线虫的毒理学影响.
- 确定氧化应激在MP引起的毒性中的作用.
主要方法:
- 紫外线照射到摄影时代DPC-MPs并诱导EPFRs.
- 线虫 (Caenorhabditis elegans) 暴露于光衰 DPC-MPs 的情况.
- 对线虫的行为,繁殖,氧化应激生物标志物 (ROS,MDA,8-OHdG) 和基因表达的分析.
- 用N-乙-l-氨酸 (NAC) 治疗以评估氧化应激抑制.
主要成果:
- 紫外线照射在DPC-MPs上产生了EPFR.
- 在相关度下,光衰的DPC-MPs减少了线虫的运动,身体长度和繁殖规模.
- 在线虫中观察到氧化应激标志物 (ROS,MDA,8-OHdG) 的增加和基因表达的改变.
- NAC治疗显著降低了毒性和氧化应激.
- 氧化应激与不良生理影响有很强的相关性.
结论:
- 在光衰 DPC-MP 上的 EPFR 诱导了线虫中的毒性.
- 氧化应激是调解这些MP的毒性作用的关键机制.
- 调查结果强调了老年议员的环境风险,以及在毒性评估中考虑EPFR的重要性.
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