相关实验视频

Updated: Jul 11, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

长非编码RNA KCNQ1OT1在癌症进展中的生物学作用

Kai Zhan¹, Huafeng Pan², Zhang Zhou³

¹Dongguan Hospital of Guangzhou University of Chinese Medicine, Dongguan 523000, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|November 17, 2023

概括

长非编码RNA KCNQ1OT1 (KCNQ1OT1) 通过稳定mRNA,驱动增殖,迁移和转移,促进癌症的进展. 这种lncRNA是一种有前途的生物标志物和治疗点,用于各种恶性瘤.

科学领域:

分子生物学分子生物学
在瘤学瘤学.
在RNA生物学,RNA生物学.

背景情况:

长非编码RNAs (lncRNAs) 越来越多地被认为是它们在癌症中的作用.
在恶性瘤中,LncRNA KCNQ1重叠转录1 (KCNQ1OT1) 经常过度表达.
KCNQ1OT1与瘤生长,转移和复发有关.

研究的目的:

审查KCNQ1OT1在各种癌症中的机制和进展.
探索KCNQ1OT1在癌症发病过程中的作用.
评估KCNQ1OT1作为潜在的诊断和治疗点.

主要方法:

对KCNQ1OT1在癌症中的功能进行文献综述.
对KCNQ1OT1参与信号通路 (PI3K/AKT,Wnt/β-catenin) 的分析.
检查KCNQ1OT1的分子机制,包括miRNA海绵化.

主要成果:

KCNQ1OT1促进瘤细胞的增殖,迁移,入侵和耐药性.
KCNQ1OT1抑制了细胞亡,并促进了上皮细胞-介质细胞过渡 (EMT).
在体内,KCNQ1OT1增强瘤生长和转移.
KCNQ1OT1通过miRNA海绵化稳定了mRNA的表达.

结论:

KCNQ1OT1在多种癌症类型中起着重要作用.
KCNQ1OT1通过调节关键癌症途径,充当致癌性 lncRNA.
KCNQ1OT1为癌症诊断和治疗提供了一个有前途的生物标志物和治疗点.

关键词:

癌症癌症癌症癌症 KCNQ1OT1 的时间长非编码RNA是什么意思一个进步的进步.信号通道的信号通道.

更多相关视频

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

mTOR Signaling and Cancer Progression

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Non-LTR Retrotransposons

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...