在NaOH/尿素水溶液中制备的硫基的结构和特性
1Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, China.
Carbohydrate research
|November 17, 2023
概括
在温和的条件下合成了具有可调节性质的新硫基 (SCs). 这些生物相容材料显示出自组装成和水凝的潜力,适合生物医学应用.
科学领域:
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
- 生物材料是一种生物材料.
背景情况:
- 奇是一种天然的多糖,是丰富的,但往往是由于溶解性和可加工性差而受到限制.
- 基的修改对于扩大其在各个领域的应用至关重要.
- 硫基 (SC) 提供增强的溶解性和独特的功能性质.
研究的目的:
- 合成一系列具有受控置换度 (DS) 和高度乙化 (DA) 的硫烯基基 (SC).
- 研究合成的SCs的结构,物理和自我组装特性.
- 评估SCs在生物医学应用中的潜力,包括水凝形成.
主要方法:
- 在NaOH/尿素水溶液中使用基和3--2-基硫酸盐 (SCHPS) 合成SC的均合成.
- 使用各种技术进行表征:1H NMR,13C NMR,FT-IR,XPS,XRD,GPC,AFM, ζ-电位,以及风湿学测量.
- 评估可溶性,自组装成微粒,以及热凝性质.
主要成果:
- 成功合成了SCs,DS范围从0.11到0.40,DA≥0.82.
- 温和的反应条件保留了基骨干,主要在C6基组上进行替代.
- 水溶性在DS ≥0.28时实现,并观察到自我组装成小粒.
- 不溶于水的SCs在37°C时形成热可逆水凝,证明了智能材料的行为.
- SCs表现出良好的生物相容性.
结论:
- 温和的合成条件产生均的硫基,具有可调的溶解性和自我组装特性.
- SCs显示出作为功能生物材料的潜力,形成和智能水凝.
- SCs的生物相容性支持它们适合于各种生物医学应用.
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