SCGN和STAT3表达与ccRCCCC的预后有关
Chong Lai1, Jingwen Gong2, Jinlong Tang3
1Department of Urology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Pathology, research and practice
|November 17, 2023
概括
清细胞细胞癌 (ccRCC) 患者可能有较好的预后,具有较低的STAT3和高的SCGN表达. 在ccRCC中,STAT3水平对于sunitinib治疗决定至关重要.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 细胞癌研究 细胞癌研究
背景情况:
- 清细胞细胞癌 (ccRCC) 是一种异质癌症,预后不佳.
- 确定预后生物标志物对于改善ccRCC患者的治疗结果至关重要.
研究的目的:
- 研究CCRCC中STAT3,PDL1和SCGN (分泌素) 的预后作用.
- 探索这些标记物的治疗选择和ccRCC亚型化潜力.
主要方法:
- 在ccRCC患者队列中分析STAT3,PDL1和SCGN表达 (TCGA,EMATAB-1980和内部队列).
- 标记物表达与患者预后,转移状态和治疗反应 (苏尼提尼布) 的相关性.
主要成果:
- 低STAT3和高SCGN表达与更好的ccRCC预后相关.
- SCGN表达在原发性和转移性病变之间没有显著差异,但在转移性ccRCC的原发性病变中较低.
- 高STAT3表达与苏尼替尼抗药性有关.
结论:
- STAT3和SCGN是ccRCC的潜在预后生物标志物.
- STAT3表达对于指导基于sunitinib的非手术治疗策略至关重要.
- SCGN可以作为ccRCC亚型分类的有价值指标.
更多相关视频
09:32Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
Published on: February 8, 2018
14.7K
06:46Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
294
相关概念视频
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Cancer Survival Analysis
356
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
356
