在放宽封锁措施后,肠道病毒流行病学的变化
Erley Lizarazo Forero1, Marjolein Knoester1, Lilli Gard1
1Department of medical Microbiology and Infection Prevention, University of Groningen, University Medical Center Groningen, The Netherlands.
概括
公共卫生封锁减少了肠道病毒 (EV) 的遗传多样性. 在封锁后,五种常见的EV基因型显示多样性减少和序列同质性增加,影响病毒循环.
科学领域:
- 病毒学 病毒学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 包括封锁在内的公共卫生措施对非SARS-CoV-2病毒的传播产生了重大影响.
- 这是一个很棒的节目,这是一个很棒的节目.
- 道效应的效应道效应.
- 观察到一些流感菌群在封锁期间消失.
- 这些措施对流传病毒,特别是肠道病毒的遗传多样性的影响仍然不清楚.
研究的目的:
- 调查封锁措施对循环肠道病毒 (EV) 遗传多样性的影响.
- 在实施公共卫生封锁措施之前和之后分析肠道病毒基因型及其遗传构成的变化.
主要方法:
- 在使用基于5'UTR的PCR的临床样本中检测到肠道病毒.
- 为了进行基因分析,获得了部分VP-1肠道病毒序列.
- 包括来自荷兰各地广泛的医疗保健提供者网络的样本.
主要成果:
- 五种肠道病毒基因型 (EV-D68,E-11,CV-A6,CV-B5,CV-A2) 显示在封锁后遗传多样性下降.
- 其中四种基因型表现出显著的序列同质性,表明聚类.
- 与封锁前相比,感染E-11和CV-B5的儿童在封锁后年龄较大.
结论:
- 在大流行期间,肠道病毒传播的减少导致了五种最常见的肠道病毒血清型中遗传多样性的减少.
- 这些发现表明,由于公共卫生干预,肠道病毒的进化动态发生了显著的变化.
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