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莱克类受体类激酶的可逆酸化可以控制西免疫力

Ran Wang¹, Chenying Li¹, Zhiyi Jia¹

¹Zhejiang Xianghu Laboratory, Department of Plant Protection, Zhejiang University, Hangzhou 310058, China.

Cell host & microbe

|November 17, 2023

概括

植物莱克受体样类激酶LORE调解了对细菌的树皮免疫力. 通过LORE和LOPP的可逆化维持免疫平衡,为番茄等作物提供抵抗策略.

科学领域:

植物免疫力植物免疫力
分子植物病理学分子植物病理学
植物细胞的信号传递.

背景情况:

模式识别受体 (PRRs) 对于植物对病原体的防御至关重要.
体免疫机制,特别是对细菌枯病原体的反应,尚不清楚.
细胞类型特异性反应在植物免疫策略中起作用.

研究的目的:

为了阐明莱克受体类激酶LORE在阿拉比多普西斯西勒姆免疫中的作用.
为了研究LORE在Ralstonia solanacearum感染时启动的信号通路.
确定控制 LORE 中介免疫反应的调节机制.

主要方法:

研究了LORE在Arabidopsis thaliana中的功能,使用Ralstonia solanacearum的遗传淘汰和感染试验.
分析了通过S761的酸化和下游信号事件的LORE激活,例如反应性氧物种的产生和细胞壁的化.
研究了2C型蛋白酸酶LOPP在调节LORE活性中的相互作用和酸化.

主要成果:

洛尔对于基底细胞免疫力对抗R. solanacearum,一种细菌枯病原体,至关重要.
洛尔激活涉及S761的酸化,触发下游防御反应.
2C型蛋白质酸酶LOPP去化LORE,减弱免疫信号并维持平衡.
在没有生长缺陷的Arabidopsis和西红中,LOPP淘汰突变对细菌枯具有增强的抵抗力.

结论:

通过LOPP对LORE的可逆酸化是西免疫的关键调节机制.
针对LOPP提供了一种潜在的策略,可以提高作物对细菌枯的抵抗力.
了解LORE-LOPP相互作用为维护植物血管系统中的免疫平衡提供了洞察力.

关键词:

拉尔斯托尼亚 (Ralstonia solanacearumarum) 是一个海洋植物.莱克受体类似激酶的受体有活性氧物种的反应性氧物种.可逆的酸化是可逆的克西勒姆免疫的免疫力

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