量化评估生殖激素水平的变异性
Ali Abbara1, Sophie Adams2, Maria Phylactou1
1Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital, London, United Kingdom; Department of Endocrinology, Imperial College Healthcare NHS Trust, London, United Kingdom.
Fertility and sterility
|November 17, 2023
概括
由于荷尔蒙的变化,单次生殖激素测量可能不会准确地反映每日水平. 了解这种变异性是临床实践中可靠的生殖激素评估的关键.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 临床化学 临床化学
背景情况:
- 生殖激素水平因脉动性分泌,日间变化和营养摄入而波动.
- 精确评估生殖激素对于诊断和管理各种内分泌疾病至关重要.
研究的目的:
- 量化单个生殖激素测量与详细的每日激素概况相比的代表性.
- 评估脉动性分泌,日间变化和养对生殖激素水平的影响.
主要方法:
- 对266名个人 (健康人和生殖障碍者) 的激素数据进行了回顾性分析.
- 详细的荷尔蒙采样在几个小时内,在以前研究的盐水和安慰剂治疗臂.
- 使用变化系数 (CV) 和来量化变量的量化.
主要成果:
- 晨间生殖激素水平通常高于每日平均水平 (例如,LH下降18.4%).
- 化激素 (LH) 的变化最大 (CV 28%),而卵泡刺激激素 (FSH) 的变化最小 (CV 8%).
- 男性的丸激素水平在饭后显著下降,并显示了早晨和下午晚些时候水平之间的相关性.
结论:
- 一个单一的生殖激素测量在代表整体每日激素特征方面存在局限性.
- 量化激素变异对于理解生殖激素评估的可靠性至关重要.
相关概念视频
01:11Variability: Analysis
143
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
The range is a simple measure of variability, indicating the difference between the highest and...
143
01:22Hormonal Regulation of the Menstrual Cycle
405
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
405