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Updated: Jul 11, 2025

Modulating Shape of Polyester Based Polymersomes using Osmotic Pressure
Published on: April 21, 2021
聚合体用于通过肠道粘膜传递蛋白质药物
Jorge Javier Muso-Cachumba1, Sa Feng2, Mona Belaid2
1School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences & Medicine, King's College London, London SE1 9NH, UK; Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, Departamento de Tecnologia Bioquímico-Farmacêutica, São Paulo, SP, Brazil.
聚合体对像抗体这样的生物制药的口服输送充满希望. 这种新的方法显著增强了肠道运输,减少了炎症标志物,可能会彻底改变炎症性肠病等疾病的治疗方法.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 口服是首选的,因为它很方便,但生物制药在胃肠道的稳定性和吸收方面面临着挑战.
- 目前生物制药的输送方法通常需要侵入性注射途径.
- 纳米系统,包括聚合体,为克服这些交付障碍提供了潜在的战略.
研究的目的:
- 评估poloxamer 401聚合体作为一种口服抗体输送系统.
- 评估聚合体封装对IgG肠上皮质透的影响.
- 在共同培养模型中确定阿达利穆马布载荷聚合体在降低促炎性细胞因子水平方面的疗效.
主要方法:
- 使用IgG-FITC装载的poloxamer 401聚合体来研究Caco-2细胞单层中肠道上皮质透.
- 采用了上皮细胞/巨细胞共同培养模型来评估阿达利木马布载入的聚合体的抗炎作用.
- 在多聚体体内对不同剂量的阿达利马布 (adalimumab) 的反应中,促炎性细胞因子 (TNF-α) 度的量化变化.
主要成果:
- 与溶液中的IgG相比,聚合体封装的IgG在Caco-2肠道单层的运输量增加了2.7倍.
- 阿达利马布载荷的聚合体显著降低了TNF-α度:1.5微克/毫升时1.5倍,3.75微克/毫升时5.5倍,15微克/毫升时2.4倍.
- 这些发现表明,口服生物制药的传递能力和治疗潜力得到了增强.
结论:
- 波洛克萨默401聚合体是一种可行的纳米系统,可以改善抗体的口服输送和肠道透.
- 这种方法显示出减少促炎反应的巨大潜力,为治疗炎症症提供了一条新的途径.
- 通过聚合体口服生物制药可以彻底改变需要全身治疗的疾病的治疗,如炎症性肠道疾病.
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