Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Karyotyping01:17

Karyotyping

61.3K
Overview
61.3K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

17.7K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.7K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.5K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.5K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

378
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
378
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

15.2K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
15.2K
DNA Microarrays02:34

DNA Microarrays

17.5K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
17.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Probiotic attributes and safety profile of AKM Lab-01: a novel <i>Akkermansia muciniphila</i> strain combating obesity and metabolic disorders in diet-induced obese mice.

Frontiers in microbiology·2026
Same author

<i>Christensenella intestinihominis</i> MNO-863 improve obesity and related metabolic disorders via SCFAs-induced GLP-1 hormone secretion.

Frontiers in nutrition·2025
Same author

Live biotherapeutic <i>enterococcus lactis</i> MNC-168 promotes the efficacy of immune checkpoint blockade in cancer therapy by activating STING pathway via bacterial membrane vesicles.

Gut microbes·2025
Same author

Prenatal diagnosis and genetic etiology analysis of talipes equinovarus by chromosomal microarray analysis.

BMC medical genomics·2023
Same author

Identification of a novel FUT1 allele with c.325_414dup in a Chinese individual with para-Bombay phenotype.

Transfusion·2023
Same author

Ni Nanocrystals Supported on Graphene Oxide: Antibacterial Agents for Synergistic Treatment of Bacterial Infections.

ACS omega·2022

相关实验视频

Updated: Jul 11, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
00:09

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.4K

双胞胎怀孕的遗传评估使用型和单核酸多态阵列分析.

Xiaoqing Wu1, Baojia Huang2, Xiaorui Xie3

  • 1Medical Genetic Diagnosis and Therapy Center of Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China; Fujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Fuzhou, Fujian, China; Department of Laboratory Medicine, Fujian Medical University, Fuzhou, Fujian, China.

Gene
|November 17, 2023
PubMed
概括

在530个双胞胎怀孕中评估了染色体异常. 双双 (DCDA) 双胞胎比单双 (MCDA) 双胞胎出现更高的形积分和复制数变异率,特别是超声波异常.

关键词:
形积分症 (Aneuploidy) 是一个副本编号变体的变体迪科里奥尼克钻石化型化 (Karyotyping) 是一种方法.一种单色质的金刚石.单核酸多态阵列 (单核酸多态阵列,简称SNP阵列)双胞胎怀孕 双胞胎怀孕是什么意思

更多相关视频

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.1K
FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.9K

相关实验视频

Last Updated: Jul 11, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
00:09

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy

Published on: August 25, 2019

9.4K
Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform
09:30

Pre-Implantation Genetic Testing for Aneuploidy on a Semiconductor Based Next-Generation Sequencing Platform

Published on: August 17, 2022

3.1K
FISH for Pre-implantation Genetic Diagnosis
07:34

FISH for Pre-implantation Genetic Diagnosis

Published on: February 23, 2011

36.9K

科学领域:

  • 围产儿医学 围产儿医学
  • 遗传学 是一个遗传学.
  • 产科 产科 产科 产科 产科

背景情况:

  • 双胞胎怀孕在产前诊断方面存在独特的挑战.
  • 染色体异常发生在相当一部分双胞胎妊娠中.
  • 在风险评估中,区分单胆双子 (MCDA) 和二胆双子 (DCDA) 双胞胎至关重要.

研究的目的:

  • 评估双胞胎怀孕中染色体异常的患病率和类型.
  • 为了比较MCDA和DCDA双胞胎之间的异常率.
  • 评估型和SNP阵列在检测这些异常时的有用性.

主要方法:

  • 在530个双胞胎怀孕中进行了型化和单核酸多态性 (SNP) 阵列分析.
  • 这些病例被分为MCDA (177) 或DCDA (353).
  • 数据分析基于质性质,临床指示和超声检测结果.

主要成果:

  • 在50个胎儿中检测到染色体异常,最常见的发现是形状.
  • 与MCDA怀孕 (10例) 相比,DCDA怀孕显示出较高的状体积率 (35例).
  • 三胞胎21是最常见的异常;SNP阵列在超声波异常的DCDA双胞胎中更频繁地发现了临床显著的副本数变异.

结论:

  • 染色体形形状是双胞胎怀孕中的主要异常.
  • 在DCDA怀孕中,特别是那些超声波异常的怀孕中,可检测的染色体异常和副本数变异的可能性更高.
  • 型和SNP阵列是双胞胎妊娠中全面产前诊断的宝贵工具.