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Updated: Jul 11, 2025

Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer

Published on: July 28, 2010

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通过调节阿斯巴酸β-基酶,高水平的2-格卢酸在胆管癌化疗中对抗DNA损伤反应

Katsuya Nagaoka1, Xuewei Bai2, Dan Liu2

  • 1Liver Research Center, Rhode Island Hospital and the Alpert Medical School of Brown University, Providence, RI, USA; Department of Gastroenterology & Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Cancer letters
|November 17, 2023
PubMed
概括

升高的2-氧格酸盐 (2-OG) 和阿斯巴酸β-化酶 (ASPH) 通过抑制DNA损伤反应 (DDRs) 来促进胆管癌 (CCA) 的化学抵抗. 向ASPH可以提高CCA中的化疗疗效.

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