夜间户外人工光和男性精子质量:中国的一项回顾性队列研究
Run Tian1, Tingting Yang2, Chenghan Xiao1
1Department of Maternal and Child Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China; Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China.
Environmental pollution (Barking, Essex : 1987)
|November 17, 2023
概括
暴露在夜间室外人工光线 (ALAN) 与人类精子质量降低有关. 较高的ALAN水平与精子运动性和线性降低相关,特别是在年轻男性中.
科学领域:
- 环境健康 环境健康
- 生殖毒理学 生殖毒理学
- 人类精子质量评估评估
背景情况:
- 全球不孕率不断上升,需要了解环境对生殖健康的影响.
- 动物研究表明,夜间人工光 (ALAN) 对精子有负面影响,但人类数据很少.
- 调查户外ALAN和人类精子参数之间的关联至关重要.
研究的目的:
- 量化慢性和急性暴露在夜间室外人工光 (ALAN) 和人类精子质量之间的关联.
- 为了确定是否增加户外ALAN水平会对成年男性的精子参数产生负面影响.
主要方法:
- 一项追溯性队列研究,涉及1991年精子捐赠候选人.
- 用多变量线性回归和受限立方线模型来分析数据.
- 精子质量参数 (运动性,线性,曲线速度,非渐进性运动性) 与室外ALAN暴露水平 (0-100nW/cm2/sr) 相比进行了评估.
主要成果:
- 慢性室外ALAN暴露的增加与精子线性 (LIN) 和曲线速度 (VCL) 的减少有关.
- 较高的ALAN水平与非进展性精子运动率 (NP) 的增加以及整体精子运动率的下降相关.
- 对急性ALAN暴露也观察到类似的负面关联,对25岁以下的男性的影响更为明显.
结论:
- 夜间室外人工光 (ALAN) 的较高水平与人类精子质量较差有关.
- 环境光污染可能是影响男性生育能力的可修改风险因素.
- 需要进一步的研究来阐明ALAN暴露对生殖健康的机制和长期影响.
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