在慢性完全胸部脊髓损伤后大脑的结构和功能变化
Jing Li1, Yi Shan1, Xiaojing Zhao1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing 100053, China.
Brain research
|November 17, 2023
概括
慢性完全胸脊髓损伤 (cctSCI) 改变了大脑结构和功能连接,影响了临床结果. 这些大脑变化与感觉运动功能的恢复有关.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 临床神经学 临床神经学
背景情况:
- 慢性完全胸脊髓损伤 (cctSCI) 在理解其长期神经效应方面存在重大挑战.
- 研究受伤后的大脑变化对于确定恢复机制和治疗点至关重要.
研究的目的:
- 为了检查cctSCI后的大脑结构和功能变化.
- 确定这些大脑变化与临床结果之间的关系.
主要方法:
- 结构性和静止状态功能性MRI在18名cctSCI患者和19名健康对照中使用.
- 基于voxel的形态测量 (VBM) 评估了灰色物质体积 (GMV) 的差异.
- 功能连接 (FC) 分析和部分相关性研究了与临床分数的关系.
主要成果:
- 脊髓损伤患者的GMV在额头和部区域下降,GMV在上额头和补充运动区域增加.
- 增加的GMV区域与对海马体和体黄层的功能连接性增加有关.
- 在功能连接和ASIA总感官运动得分之间发现了显著的正相关性 (p=0.001,r=0.746).
结论:
- cctSCI诱导大脑结构和功能重组,影响视觉,认知,感官和运动区域.
- 这些发现提高了对脑损伤机制和脊髓损伤后神经可塑性的理解.
- 确定的大脑变化为跟踪治疗疗效和指导治疗策略提供了潜在的生物标志物.
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