与认知变化相关的阿尔茨海默病多基因风险评分:来自普通人口的代表样本在16年内进行了跟踪

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Jenna Najar1, Valgeir Thorvaldsson2, Silke Kern3

  • 1Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Sweden; Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden; Department of Human Genetics, Genomics of Neurodegenerative Diseases and Aging at the Amsterdam University Medical Center, Amsterdam, the Netherlands.

Neurobiology of disease
|November 17, 2023
PubMed
概括

对阿尔茨海默病 (AD) 的遗传倾向预测了16岁以上老年人的认知能力下降. 然而,对一般认知能力的多基因风险评分并没有影响随时间推移的认知变化.

关键词:
这是APOE基因型.认知能力 认知能力 认知能力认知能力下降 认知能力下降多基因风险得分的多基因风险得分.

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