遗传缺陷对瑞典乳牛流产的影响
P Ask-Gullstrand1, E Strandberg1, R Båge2
1Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden.
Journal of dairy science
|November 17, 2023
概括
携带BTA12和Holstein Haplotype 3 (HH3) 遗传缺陷的状态显著增加了妊娠流产,并降低了奶牛的受孕率. 避免这些有风险的交配可以提高生育能力,减少繁殖计划中的损失.
科学领域:
- 动物遗传学动物遗传学
- 生殖生物学 生殖生物学
- 乳牛养殖 乳牛养殖 乳牛养殖
背景情况:
- 致命的衰退性遗传缺陷对乳牛生育和育种计划构成重大挑战.
- 了解特定遗传缺陷对怀孕维持的影响对于有效管理至关重要.
- 瑞典乳牛种群受到各种遗传病症的影响,包括艾尔夏尔哈普洛型1和2,BTA12,BTA23,布朗瑞士哈普洛型2和霍尔斯坦哈普洛型1,3,4,6和7.
研究的目的:
- 评估10种致命的衰退性遗传缺陷的载体身份对瑞典乳牛妊娠维持的影响.
- 专门研究BTA12和Holstein Haplotype 3 (HH3) 携带者身份对受孕率 (CR),第一次到最后一次服务间隔 (FLS) 和牛奶产量的影响.
主要方法:
- 利用了瑞典牛奶记录系统中的1429只牛群的数据以及来自北欧牛基因评估的基因载体状态信息.
- 分析了来自28432头红乳牛 (RDC) 和22018头荷尔斯坦雌性158,795次授精的数据.
- 采用了通用的线性混合模型来估计妊娠损失和CR的几率比率 (OR),以及分析妊娠损失,CR,FLS和牛奶生产特征的线性混合模型.
主要成果:
- 怀孕流产主要发生在输精后的第一个月内.
- 涉及BTA12 (OR = 1.79) 和HH3 (OR = 1.77) 携带者的交配显示出与非危险交配相比,怀孕丧失的几率明显更高.
- 有风险的交配表明受孕率降低 (OR = 0.62对于BTA12,OR = 0.63对于HH3). 携带BTA12的母体也经历了更长的FLS和增加的牛奶产量.
结论:
- 携带BTA12和HH3的状态显著影响了瑞典奶牛的怀孕维持和受孕率.
- 避免携带这些特定遗传缺陷的携带者之间的交配是提高生育能力和减少怀孕流产的可行策略.
- 将这些发现应用于育种计划可以有助于提高生殖效率并减少与遗传缺陷相关的经济损失.
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