患有Mycobacterium abscessus复杂肺病的患者的微生物持久性:患病率,预测因素和对进展的影响
Ling-Kai Chang1, Ping-Huai Wang2, Tai-Fen Lee3
1Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch BioMedical Park Hospital, Zhubei City, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan.
概括
持续性Mycobacterium复杂性肺病 (MABC-LD) 在30.7%的患者中发生. 最初的酸速染色等级和放射评分预测持续的MABC阳性,表明潜在的疾病进展.
科学领域:
- 医学微生物学 医学微生物学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 菌根复杂性肺病 (MABC-LD) 可能涉及持久性感染.
- 在MABC-LD中持续MABC增长的流行率,风险因素和临床影响尚未得到充分了解.
研究的目的:
- 调查MABC-LD.中持续培养阳性 (MABC-PP) 的流行率.
- 为了确定MABC-PP的预测因子.
- 分析MABC-PP与疾病进展之间的关联.
主要方法:
- 在台湾北部的两个医疗中心进行了回顾性研究.
- 招募的患者有MABC-LD.
- 研究了MABC-PP的患病率和预测因素,并分析了与放射性或临床进展的关联.
主要成果:
- 在189名患者中,有58名 (30.7%) 患有MABC-PP.
- 对于MABC-PP的独立预测因素包括更高的放射性得分和强烈阳性 (3-4+) 初始酸速染色 (AFS).
- MABC-PP和最高的AFS等级独立地与MABC-LD进展相关 (当两种因素都存在时调整后的危险比为3.56).
结论:
- MABC-PP影响了30.7%的MABC-LD患者.
- 最初的AFS等级和X光学得分预测了MABC-PP.
- MABC-PP和高AFS等级可能表明MABC-LD的进展.
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