在脊髓损伤后早期发展出高凝血-低纤维素分析状态
Andrew J Park1, Vinicius P Garcia2, Jared J Greiner2
1Rocky Mountain Regional Spinal Injury System, Craig Hospital, Englewood, CO; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, CO.
Archives of physical medicine and rehabilitation
|November 17, 2023
概括
脊髓损伤 (SCI) 与前血栓状况有关,血液凝固因子升高,纤维素分解中断. 这些早期变化可能会增加SCI患者心脏病发作和中风的风险.
科学领域:
- 血液学 血液学 血液学
- 神经学 神经学
- 心血管科学 心血管科学
背景情况:
- 脊髓损伤 (SCI) 可以影响系统生理过程.
- 了解SCI后的静血变化对于管理相关风险至关重要.
研究的目的:
- 调查脊髓损伤 (SCI) 与凝血和纤维溶解因子的变化之间的关联.
- 确定这些变化是否有助于血栓形成和心肌梗塞和中风等动脉血栓事件.
主要方法:
- 一项横截面研究,将16名患有亚急性四肢的成年人与14名未受伤的成年人进行了比较.
- 测量循环标记物,包括·维勒布兰德因子,凝血因子VII,VIII,X,组织等离子素激活剂 (t-PA),等离子素激活剂抑制剂-1 (PAI-1),以及D-二次体.
主要成果:
- 与对照人群相比,患有SCI的成年人表现出明显更高的结血因子VII,VIII和X水平.
- 纤维溶解标记被破坏,在SCI组中明显增加了t-PA抗原,PAI-1抗原和PAI-1活性.
- 患有SCI的成年人中,D-二元度显著更高,表明纤维素形成增加.
结论:
- 亚急性四肢完全运动性SCI与前血栓性静血形状相关.
- 凝血和纤维解质的不良变化发生在SCI后的早期.
- 这些静血性变化可能导致SCI患者观察到的动脉血栓风险升高.
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