最近在向大脑输送和蛋白质疗法的进展
Sanchit Arora1, Tania Bajaj1, Jayant Kumar1
1Maa Saraswati College of Pharmacy, Abohar-Sito Road, VPO Kala Tibba, Punjab, India (S.A.); Department of Pharmaceutics, ISF College of Pharmacy, Punjab, India Affiliated to I.K. Gujral Punjab Technical University, formerly Punjab Technical University, Punjab, India (T.B., C.S.); Department of Pharmaceutical Sciences, School of Sciences, Hemvati Nandan Bahuguna Garhwal University (A Central University), Uttarakhand, India (J.K., M.G., C.S.); and Department of Pharmacology, ISF College of Pharmacy, Punjab, India (A.S.).
通过血脑屏障 (BBB) 传递蛋白质和疗法是治疗神经疾病的挑战. 本综述探讨了纳米粒子输送系统和战略,以克服BBB的局限性,有效地输送大脑药物.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 蛋白质和对于神经系统的沟通至关重要,但它们面临着进入大脑的重大障碍.
- 血脑屏障 (BBB) 限制了诸如蛋白质和等大分子的通过.
- 目前的药物输送方法往往缺乏治疗性脑度的必要优化.
研究的目的:
- 审查各种药物输送系统,用于在BBB中运输神经蛋白和神经.
- 突出基于纳米粒子的脑药物输送策略的潜力.
- 讨论神经系统疾病的蛋白质和治疗方法的挑战和未来方向.
主要方法:
- 关于进入大脑的药物输送系统的现有文献的审查.
- 纳米粒子配方的分析,包括聚合物,脂质体和纳米凝.
- 讨论嵌合体系统和转细胞的链接器策略.
主要成果:
- 像PLGA,脂质体和纳米结构脂质载体这样的纳米颗粒配方对BBB运输有希望.
- 化学体系统提供了一种在BBB中促进转细胞形成的策略.
- 传递系统的生理优化对于实现治疗疗效至关重要.
结论:
- 有效地向大脑输送蛋白质和治疗药物需要克服BBB的局限性.
- 纳米技术为增强大脑药物输送提供了多种平台.
- 需要进一步的研究和开发来优化这些系统用于治疗大脑疾病的临床应用.
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