对SF3B1-SUGP1接口的表征揭示了多种癌症突变如何导致mRNA错误拼接

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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

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Jian Zhang1, Jindou Xie2,3, Ji Huang1

  • 1Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Genes & development
|November 17, 2023
PubMed
概括

结合体基因SF3B1中的与癌症相关的突变破坏了它与结合因子SUGP1的相互作用. 这种分子洞察力揭示了这些突变如何影响拼接精度,并有助于癌症的发展.

关键词:
阿尔法折叠-多元化DHX15 DHX15 的时间.在G-patch上使用.骨髓发育不良综合征拼接细胞突变的突变

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