老年疗法,癌症,以及衰老
Lodovico Balducci1, Claire Falandry2, Silvio Monfardini3
1Senior Member Emeritus Moffitt Cancer Center, Tampa, FL, USA.
Journal of geriatric oncology
|November 17, 2023
概括
消除衰老细胞的老年疗法在预防和治疗老年人癌症方面表现有前途. 这种方法可以减少癌症发生率,改善治疗耐受性,并预防复发.
科学领域:
- 老年病学和瘤学
- 细胞衰老 细胞衰老
- 癌症生物学 癌症生物学
背景情况:
- 细胞衰老是细胞停止分裂并表现出衰老相关的分泌表型 (SASP) 的状态.
- 该SASP有助于与衰老相关的疾病和残疾,包括癌症.
- 衰老细胞,如纤维细胞和脂肪细胞,在衰老中发挥作用.
研究的目的:
- 审查老年人癌症预防和治疗中老年疗法的影响.
- 探索消除衰老细胞以对抗癌症的潜力.
主要方法:
- 一个基于Medline搜索的叙事评论,使用关键词:老年疗法,老年溶解和老年形剂.
- 对细胞培养,小鼠模型和正在进行的临床试验的研究结果的分析.
主要成果:
- 一些药物 (甲胺,拉巴胺素,达沙替尼,奎尔塞丁,菲塞等) 可以消除衰老的细胞.
- 疗在动物模型中显示出延长寿命和降低癌症发病率的潜力.
- 衰老的瘤细胞与瘤复发和治疗耐药性有关.
结论:
- 疗可能通过减少癌症发生率和攻击性,显著影响癌症管理.
- 它有可能提高对癌症治疗的耐受性,并预防复发.
- 疗也可以改善化疗引起的并发症.
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