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相关概念视频

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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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The gonads, namely the testes in males and the ovaries in females, are pivotal in producing gonadal hormones that orchestrate the intricate processes of sexual development and reproduction.
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The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
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The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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妊娠期丸激素升高会影响血管和子宫胎盘功能.

Sathish Kumar1, Ruolin Song2, Jay S Mishra2

  • 1Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, 53706, USA; Department of Obstetrics and Gynecology, School of Medicine and Public Health, University of Wisconsin, Madison, WI, 53792, USA.

Placenta
|November 17, 2023
PubMed
概括

怀孕期间丸激素 (T) 升高可能会通过通过雄激素受体 (AR) 影响母亲的心血管和胎盘功能,从而导致妊娠前. 本综述审查了支持这种作用在妊娠高血压疾病中的临床和动物证据.

关键词:
雄激素是一种基.脑内皮质 (Endothelium) 是一个内皮.营养物质的运输 营养物质的运输胎盘 胎盘 胎盘 胎盘孕前症 孕前症热细胞 热细胞

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科学领域:

  • 生殖生物学 生殖生物学
  • 孕产妇与胎儿的医学
  • 内分泌学 在内分泌学.

背景情况:

  • 适当的母体血管适应对于胎儿发育至关重要.
  • 这些适应的失败增加了产前并发症的风险,如孕前.
  • 雄激素,特别是丸激素,因其水平升高和与血管功能障碍的相关性,涉及到孕前的发病.

研究的目的:

  • 批判性地评估一项假设,即雄激素受体 (AR) 介导的活动在孕前中起着重要作用.
  • 审查临床和临床前证据,将雄激素与怀孕期间母亲的心血管和胎盘功能联系起来.

主要方法:

  • 临床数据的综述从预先怀孕的怀孕,注意到水平和AR表达.
  • 对模仿怀孕期间高的动物研究结果的分析.
  • 综合证据,将雄激素活性与子宫前的关键特征联系起来.

主要成果:

  • 孕前妇女表现出血中 (T) 水平升高 (2至3倍),与血管功能障碍相关.
  • 增加的雄激素受体 (AR) 水平在胎盘组织中被观察到.
  • 高T的动物模型重现了孕前的特征:高血压,内皮功能障碍,螺旋动脉改造受损,胎盘缺氧和胎儿生长限制.

结论:

  • 强烈建议以雄激素受体为媒介的活性在孕前的临床表现中发挥重要作用.
  • 高水平的丸激素及其对母亲血管系统和胎盘发育的影响是孕前炎症研究中需要考虑的关键因素.
  • 对AR途径进行进一步的研究是有必要的,以了解并潜在地治疗妊娠前.