鼻气道炎症反应和病原体检测在患有囊性纤维化的婴儿
Benjamin T Kopp1, Sydney E Ross2, Dinesh Bojja1
1Division of Pulmonology, Asthma, Cystic Fibrosis, and Sleep, Emory University School of Medicine, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA.
概括
鼻液分析可以检测患有囊性纤维化 (CF) 的婴儿的呼吸道炎症. 炎症标志物如IL-6和中性粒细胞弹性酶 (NE) 在病毒感染和肺部恶化 (PEx) 期间增加.
科学领域:
- 儿科肺病学 儿科肺病学
- 炎症生物标志物 炎症生物标志物
- 囊性纤维化研究 囊性纤维化研究
背景情况:
- 在患有囊性纤维化 (CF) 的婴儿中,非侵入性检测呼吸道炎症是具有挑战性的.
- 假设鼻液中的炎症标志物表明病毒感染或肺部恶化 (PEx) 期间的炎症.
研究的目的:
- 在患有CF的婴儿的鼻液中测量炎症标记物 (IL-1β,IL-6,IL-8,IL-10,IL-17A,中性粒细胞弹性酶 (NE),TNF-α).
- 评估这些标志物是否与病毒感染,PEx或环境暴露如烟雾相关.
主要方法:
- 收集了34名患有CF的婴儿的鼻液,拭子和头发.
- 分析了鼻液的细胞因子和鼻的呼吸道病毒.
- 在头发样本中测量尼古丁,并根据病毒状况,PEx和烟雾暴露,比较细胞因子水平.
主要成果:
- 在患有呼吸道病毒的婴儿中观察到IL-6,IL-8,TNF-α和NE的度增加.
- 在患有病毒感染和PEx的婴儿中,IL-17A降低.
- 在可检测尼古丁水平的婴儿中发现IL-6,IL-10和NE水平升高.
结论:
- 非侵入性鼻液采集是一种可行的方法,用于识别患有CF的婴儿的呼吸道炎症.
- 这种方法可以帮助监测与临床变化和环境暴露相关的炎症.
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