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椎间盘退化和骨矿物质密度:双向孟德尔随机化研究

Jie Zhao1, Jingyu Wang1, Haixu Xu2

  • 1Department of Clinical Lab, Tianjin First Central Hospital, 300192, Tianjin, China.

Calcified tissue international
|November 17, 2023
PubMed
概括

较低的骨矿物质密度 (BMD) 因果上增加了椎间盘退化 (IVDD) 的风险. 具体来说,脚跟,全身,大腿部和腰椎的BMD显著影响IVDD的发展,没有证据表明IVDD会影响BMD.

关键词:
骨矿物质密度 骨矿物质密度全基因组关联研究研究.椎间盘退化 椎间盘退化门德尔的随机化骨质疏松症是一种骨质疏松症.

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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