在五个或更少毛囊的体外受精周期中活产率
Michelle J Bayefsky1, Sarah D Cascante2, David H McCulloh2,3
1New York University Langone Health, Grossman School of Medicine, 462 First Avenue, Ninth Floor, New York, NY, 10016, USA. michelle.bayefsky@nyulangone.org.
Journal of assisted reproduction and genetics
|November 17, 2023
概括
在不到五个卵泡的体外受精 (IVF) 周期中,活产率 (LBR) 较低,特别是在老年患者中. 这些数据有助于患者决定是否继续取卵.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精过程中受精.
- 临床产科和妇科 临床产科和妇科
背景情况:
- 卵泡计数是体外受精 (IVF) 卵巢反应的关键指标.
- 卵巢储备减少的患者通常有较少的卵泡,这引发了关于试管婴儿周期可行性的疑问.
研究的目的:
- 评估在试管婴儿周期中活产率 (LBRs),其特点是触发时卵泡数量低 (≤5).
- 提供数据,以帮助患有卵泡数量低的患者做出有关卵细胞检索的明智决策.
主要方法:
- 在2016-2020年期间,对IVF周期产生的<10个卵子细胞的回顾性队列研究.
- 纳入标准:触发日<5个毛囊>14毫米.
- 主要结局:每次获取 (新鲜或冷转移) 的LBR;次要结局:卵细胞产量,受精,胚胎细胞发育和euploidy率.
主要成果:
- 分析了1502个周期;卵泡数量与卵细胞产量,受精和胚胎细胞发育有显著的相关性 (p < 0.001).
- 活产率 (LBRs) 根据所有年龄组的毛囊数量有显著差异 (p < 0.001).
- 对于41岁以上的患者,LBR在1-3个毛囊中为<5%,在4-5个毛囊中为<15%. 在35-40岁的患者中,LBR在1-3个毛囊时为<20%,在4-5个毛囊时为25-40%.
结论:
- 活产率随着更高的毛囊数量而增加.
- 对于少于五个卵泡的患者,特定的LBR数据可以帮助在IVF检索的情感,身体和财务方面做出决定.
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