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Updated: Jul 10, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
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PARP 抑制剂耐药性的机制

Mark J O'Connor1, Josep V Forment2

  • 1Oncology R&D, AstraZeneca, Discovery Centre, Cambridge Biomedical Campus, 1 Francis Crick Avenue, Cambridge, CB2 0AA, UK. mark.j.oconnor@astrazeneca.com.

Cancer treatment and research
|November 17, 2023
PubMed
概括

聚基酶 (PARP) 抑制剂是有效的癌症药物,向DNA损伤反应. 然而,了解PARP抑制剂耐药机制对于改善各种癌症患者的治疗结果至关重要.

关键词:
这是一个ATRATRATRATR.同类重组修复 (HRR)低形突变变种的突变变种通过微同学介导的末端连接.PARP 抑制剂 (PARPi) 的耐药性聚合酶甲基酶是什么?复制应激是复制应激的一种.逆转突变是一种逆转突变.在WEE1中,WEE1是WEE1的代名词.

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