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Updated: Jul 10, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
09:44

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction

Published on: January 29, 2019

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在癌症医学中准ATR

Carolina Salguero1, Christian Valladolid1, Helen M R Robinson2

  • 1Department of Investigational Cancer Therapeutics (Phase I Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Cancer treatment and research
|November 17, 2023
PubMed
概括

在临床试验中,阿塔克西亚电脉切割和Rad3相关 (ATR) 蛋白抑制剂是有前途的癌症药物. 验证生物标志物是优化患者选择和FDA批准治疗窗口的关键.

关键词:
富含AT互动域含有蛋白1A (ARID1A) 的缺陷作为ATR抑制剂的使用.ATAXIA telangiectasia和与Rad3相关的蛋白质 (ATR) 的发生泰朗格iectasia-mutated (ATM) 缺陷的阿塔克西亚缺陷.基因损伤反应 (DDR) 是一种对DNA损伤的反应.这是一种PARP抑制剂.

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