感染后勃起功能障碍风险 - 将COVID-19与其他常见的急性病毒感染进行比较:分析大型国家索赔数据库
Una E Choi1, Corey Able2, Aurora J Grutman1
1The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
International journal of impotence research
|November 18, 2023
概括
在COVID-19感染后勃起功能障碍 (ED) 的风险并不高于大多数病毒性疾病. 与COVID-19相比,疹带来了更大的ED风险,这表明炎症在感染后的ED中起作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 勃起功能障碍 (ED) 是一个越来越令人担忧的问题,与病毒感染的潜在联系.
- 与其他病毒相比,冠状病毒-19 (COVID-19) 感染后的ED的特定风险尚不清楚.
研究的目的:
- 评估COVID-19感染后患者发展ED的风险.
- 为了将这种风险与其他常见病毒感染患者的ED发病率进行比较.
主要方法:
- 使用TriNetX COVID-19研究网络进行的一项大型国家队列研究.
- 倾向性得分匹配用于比较感染COVID-19的男性 (≥18岁) 与流感,RSV,肠道病毒,病毒性肝炎,单核病和疹病毒的队列.
- 新的ED诊断或固酶-5抑制剂 (PDE5i) 处方是主要结局,但不包括以前的ED或相关病史.
主要成果:
- 与疹患者相比,COVID-19患者患ED或需要PDE5i处方的可能性较低 (RR:0.37).
- 与没有急性病毒性疾病的患者相比,COVID-19患者更有可能发展ED或需要PDE5i处方 (RR: 1.33).
- 在COVID-19和研究的大多数其他常见病毒感染之间,没有发现ED风险或PDE5i处方的显著差异.
结论:
- 与大多数其他急性病毒性疾病相比,COVID-19感染与ED的风险不高.
- 疹疹感染显示ED感染后的风险比COVID-19更高.
- 这些发现表明,急性感染中常见的潜在炎症机制可能会导致ED风险.
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