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评估大脑损伤,疾病和任务对认知疲劳的影响
Glenn R Wylie1,2,3, Helen M Genova4,5, Bing Yao4,5
1Rocco Ortenzio Neuroimaging Center, Kessler Foundation, 1199 Pleasant Valley Way, West Orange, NJ, 07052, USA. gwylie@kesslerfoundation.org.
Scientific reports
|November 18, 2023
概括
认知疲劳 (CF) 在脑损伤或疾病后很常见. 这项研究发现,尾状核和丘脑是参与多发性硬化症,创伤性脑损伤和对照组中CF的关键大脑区域.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 神经学 神经学
背景情况:
- 认知疲劳 (Cognitive fatigue,CF) 是神经损伤或疾病后的一个常见和致残的症状.
- 了解CF的神经基础对于开发有效的干预措施至关重要.
研究的目的:
- 研究认知疲劳,行为表现和大脑激活之间的关系.
- 为了比较这些人群之间的关系与神经疾病 (多发性硬化症),神经损伤 (创伤性脑损伤) 和健康对照.
主要方法:
- 结合了两项涉及多发性硬化症 (MS),创伤性脑损伤 (TBI) 和对照组的横截面研究的数据.
- 在使用两个不同的任务获取神经成像数据时诱导认知疲劳.
- 分析行为表现 (响应时间) 和大脑激活模式.
主要成果:
- 与对照组相比,TBI组的认知疲劳水平显著更高,MS组的认知疲劳水平趋势更高.
- 在所有组中,增加的认知疲劳与更长的反应时间有关.
- 在所有组中,尾状核和丘脑中的大脑激活与认知疲劳一致相关.
结论:
- 尾状核和丘脑似乎是认知疲劳的核心.
- 尾状核的特定背部区域可能对神经损伤类型敏感,区分MS和TBI.
- 这些发现突出了特定的皮下结构在神经疾病后的认知疲劳中的作用.
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