表面功能化影响口服中性纳米颗粒的保留和生物分布,在大肠炎小鼠模型中
Roman Schmid1, Meta Volcic2, Stephan Fischer3
1Inorganic Chemistry II, Ulm University, 89081, Ulm, Germany.
Scientific reports
|November 18, 2023
概括
表面功能化的半孔二氧化纳米颗粒 (MSN) 显示可调节的胃肠道 (GIT) 积累. 使用聚乙烯糖醇 (PEG) 或氨酸 (HA) 的功能化影响健康和炎症条件下的颗粒分布.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 胃肠病学 胃肠病学
背景情况:
- 口服药物输送面临着诸如过早降解和胃肠道 (GIT) 中的生物可用性差等挑战.
- 长时间的GIT停留时间对于治疗肠道清除增加的疾病至关重要,例如炎症性肠道疾病 (IBD).
研究的目的:
- 在口服后合成和研究杆状中孔性纳米粒子 (MSN) 的体内生物分布,这些纳米粒子与聚乙烯糖醇 (PEG) 或酸 (HA) 功能化.
- 探索MSNs的表面功能化如何影响其在健康和炎症肠道环境中的积累和保留.
主要方法:
- 用PEG或HA功能化的棒状MSNs的合成.
- 在健康小鼠和与硫酸 (DSS) 诱导的肠炎症的小鼠进行体内生物分布研究.
- 使用Caco-2/Raji和产生粘液的Caco-2/Raji/HT29细胞共同培养模型进行体外粘附研究.
主要成果:
- 在健康小鼠的下部肠道中积累了PEGylated MSN;HA功能化的MSN在炎症肠道中增加了保留.
- MSN的系统吸收通常很低,但在炎症小鼠的器官中检测到了一些颗粒,特别是MSN-PEG.
- 试验室粘附结果与体内行为相关,但再吸收不能完全反映炎症组织侵蚀.
结论:
- MSN的表面功能化可以调节它们在健康和炎症状态下在GIT内积累和保留.
- 这些发现对设计基于纳米颗粒的输送系统具有重大意义,用于口服,特别是用于IBD治疗.
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