"跨国网络队列分析中的急性后COVID-19症状的负担"
Kristin Kostka1, Elena Roel2,3, Nhung T H Trinh4
1Pharmaco- and Device Epidemiology Group, CSM, NDORMS, University of Oxford, Oxford, United Kingdom.
Nature communications
|November 18, 2023
概括
随着时间的推移,COVID-19 (2019年冠状病毒疾病) 感染后的持续症状下降,但在再次感染后更为常见. 与对照组相比,改变气味或味道仍然是COVID-19病例的关键差异化因素.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 在急性COVID-19 (冠状病毒疾病2019) 之后持续的症状代表了全球健康的重大负担.
- 了解后急性COVID-19症状的特征和风险因素对于有效的管理和干预至关重要.
研究的目的:
- 描述后急性COVID-19症状并确定持久性疾病的关键指标.
- 估计一般人群和COVID-19患者中持续症状的发病率.
- 为了比较第一次感染和再感染之间的持续症状.
主要方法:
- 一项大型队列研究,利用来自西班牙和英国的初级保健电子健康记录.
- 包括超过856,840例首次COVID-19病例,72,422例再感染,以及310万例检测阴性对照.
- 分析症状频率,发病率,以及COVID-19病例和对照组之间的比较,包括匹配的测试阴性个体.
主要成果:
- 在整个研究期间,COVID-19病例中经历持续后急性症状的比例下降.
- 与检测负的对照组相比,在COVID-19患者中始终观察到异味或味道变化的风险增加.
- 持续症状在COVID-19再感染后比初级感染后更为普遍.
结论:
- 虽然持续性后急性COVID-19症状的整体发病率已经下降,但再感染的风险更大.
- 味道和气味的改变是区分COVID-19病例的重要指标.
- 需要进一步的研究来完善长期COVID的定义,并制定干预措施以减轻其影响.
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