口腔病原体通过促进小鼠的Th1细胞透来加剧帕金森病
Xue-Bing Bai1,2,3,4,5,6,7, Shuo Xu2,3,4,5,6,7,8, Lu-Jun Zhou1,2,3,4,5,6,7
1Department of General Dentistry, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, China.
Microbiome
|November 18, 2023
概括
牙周炎加剧了帕金森病 (PD) 的运动功能障碍和神经退行. 口腔细菌Veillonella parvula和Streptococcus mutans通过改变肠道微生物群和激活PD小鼠的免疫反应来驱动这些影响.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 帕金森病 (PD) 是一种神经退行性疾病,没有治疗方法,牙周炎是相关的传染病.
- 以前的研究表明牙周炎和PD之间存在联系,但缺乏直接证据.
- 这项研究调查了带有下斑块 (LIP-SP) 的带诱发性牙周炎对PD小鼠模型的影响.
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