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Updated: Jul 10, 2025

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
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通过依赖于STAT4的序列内效应,TIGIT可以逆转IFN-α促进的Th1-类Tregs

Shihan Yu1,2, Jia Gu1,3, Rui Wang1

  • 1Department of Pediatrics, The First Hospital of China Medical University, No.155, Nanjingbei Street, Heping District, Shenyang, 110001, China.

Arthritis research & therapy
|November 18, 2023
PubMed
概括

干扰素-α (IFN-α) 通过促进Th1-类Tregs来驱动狼中调节性T细胞 (Treg) 功能障碍. 激活TIGIT可以恢复Treg功能,为系统性红斑狼 (SLE) 提供潜在的治疗策略.

关键词:
一个名为IFN-α的一个小小的东西.序列效应是一个连续的效应.这是一个紧张的紧张.类似于Th1的Treg.

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