阴道微生物组变化与分娩期间使用波维胺之间的关联
Hongping Li1, Hongqin Zhang2, Linhua Geng3
1Shenzhen Children's Hospital, Shenzhen, 518000, China.
BMC microbiology
|November 18, 2023
概括
在分娩期间使用Povidone会改变阴道微生物群,减少有益的乳酸菌,增加潜在的有害细菌,如Pseudomonas和Ralstonia. 较高的剂量导致阴道微生物群体的更显著变化.
科学领域:
- 微生物学 微生物学
- 产科 产科 产科 产科 产科
- 妇科 妇科医生 妇科
背景情况:
- 阴道微生物群是一个复杂的微生物群落,受到各种因素的影响.
- 波维在分娩期间使用,以防止上升感染.
- 波维对产后阴道微生物群的影响需要调查.
研究的目的:
- 为了确定波维在分娩期间对母亲的阴道微生物群的影响.
- 评估波维暴露后阴道微生物群体的剂量依赖性变化.
主要方法:
- 招募了67名女性,并将她们分为低,中,高波维剂量组.
- 在分娩前和分娩后立即收集的阴道拭子样本.
- 使用16S rRNA测序来表征微生物群落,并使用ZicoSeq软件分析差异丰度.
主要成果:
- 波维在分娩后显著降低了乳杆菌的丰富性,并增加了整体微生物多样性.
- 较高剂量的povidone与乳酸菌的较大减少和 Pseudomonas 和 Ralstonia 的增加相关.
- 观察到与糖降解相关的功能代谢途径的显著变化,随着剂量的增加.
结论:
- 在分娩期间使用povidone与阴道微生物组的显著变化有关.
- 观察到的变化取决于剂量,较高的度导致更明显的变化.
- 需要进一步进行纵向研究,以了解对母亲和婴儿微生物组的长期影响.
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