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在健康人群中估计膜过率与年龄相关的变化的不同方程
Lu Wei1, Xue Shen1, Juan Zhang1
1Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.
BMC nephrology
|November 18, 2023
概括
在健康的中国成年人中,功能衰老 (eGFR) 趋势在CKD-EPI,FAS和Xiangya方程之间存在差异. 这些与年龄相关的方程特异性差异对于准确评估功能至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 老年学是一门学科.
- 生物统计学 生物统计学
背景情况:
- 评估与年龄相关的功能下降对于健康的衰老至关重要.
- 该研究重点关注中国人口,这是全球卫生研究的关键人口统计数据.
研究的目的:
- 评估CKD-EPI,FAS和Xiangya方程在估计膜过率 (eGFR) 估计年龄相关趋势中的性能.
- 调查这些方程对于评估中国人的健康脏衰老的适用性.
主要方法:
- 对36911名健康的中国人跨年龄组 (10年间隔) 的eGFR趋势的分析.
- 使用通用线性回归来分析下降率和与布兰德-阿尔特曼图表进行等式一致的类内相关系数 (ICC).
- 按性别分层分析以确定eGFR衰老中的性别特异性模式.
主要成果:
- CKD-EPI和Xiangya方程显示,从18岁开始的eGFR下降;FAS显示稳定到40岁,然后下降速度更快.
- 女性表现出更高的eGFR水平,但与男性相比,下降速度更快.
- 在CKD-EPI和FAS (ICC 0.818-0.920) 之间发现了良好的协议,而与西安雅的协议是70年以下的不良到适度,但70年以上的良好.
结论:
- 在健康的中国人中,CKD-EPI,FAS和雅方程估计的与年龄相关的eGFR趋势存在显著差异.
- 建议在临床实践和初级医疗保健中考虑这些方程特异性和与年龄相关的变化,以准确评估功能.
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