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产前乙醇暴露和胎儿神经内分泌代谢编程的变化

Liang Liu^1,2, Yinxian Wen^1,2, Qubo Ni^1,2

¹Department of Orthopedic Surgery, Joint Disease Research Center of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

Biological research

|November 18, 2023

概括

产前接触乙醇 (PEE) 会损害后代的发育,导致器官毒性并增加慢性疾病的风险. PEE改变了表观遗传修饰和神经内分泌编程,导致长期的健康问题.

科学领域:

发展性毒理学发展性毒理学
神经内分泌学神经内分泌学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

产前乙醇暴露 (PEE) 广泛存在,并与子宫内生长迟缓 (IUGR) 和多器官发育毒性有关.
PEE可以增加后代对慢性疾病的易感性,如成年时的神经精神和代谢障碍.
乙醇通过直接毒性和间接通过母体葡萄皮质激素影响胎儿发育,改变表观遗传修饰和器官编程.

研究的目的:

审查PEE引起的发育毒性和器官功能改变.
阐明PEE影响背后的神经内分泌代谢编程机制.
为预防和治疗乙醇发育毒性和胎儿引起的疾病提供见解.

主要方法:

对PEE对后代发育的影响进行现有研究的审查.
分析乙醇的直接和间接 (通过葡萄糖皮质激素) 影响.
对表观遗传修饰和神经内分泌轴编程的检查 (HPA,GC-IGF1).

主要成果:

在多个器官中,PEE会导致直接的发育毒性.
乙醇暴露会改变神经内分泌轴 (HPA,GC-IGF1),影响IUGR和成人疾病易感性的编程.
诸如乙醇代谢,胎盘功能和组织敏感度等因素会影响毒性严重程度和性别差异.

结论:

在不良条件下,PEE会诱导后代的"节的表型"和"赶上增长",增加疾病风险.
了解PEE的机制对于预防胎儿起源的疾病至关重要.
这一审查为管理乙醇发育毒性提供了新的视角.

关键词:

健康和疾病的发展起源 (DOHaD)葡萄糖皮质类皮质类药物在子宫内编程.神经内分泌代谢的新陈代谢在产前暴露于乙醇.

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