从随机临床试验中预测有暴力史的男性的磨损
Natalie Doring1, Ye In Jane Hwang2, Emaediong Akpanekpo2
1School of Population Health, University of New South Wales, Sydney, NSW, Australia. n.doring@unsw.edu.au.
Trials
|November 18, 2023
概括
临床试验中断是一个重大问题,特别是对司法参与的个人来说. 预测消耗的关键因素包括年龄,教育,社会支持,精神病史和之前的监禁时间.
科学领域:
- 临床心理学 临床心理学
- 法医心理学 法医心理学
- 心理药理学 心理药理学
背景情况:
- 防止参与者退出 (消耗) 对于临床试验的有效性至关重要.
- 涉及司法的人口在招聘和保留方面存在独特的挑战.
- 了解消耗因素对于改善弱势群体研究结果至关重要.
研究的目的:
- 在一项涉及司法人员的临床试验中,确定与退学相关的因素.
- 检查选择性血清素再吸收抑制剂 (SSRI) 试验中的消耗预测因子,以减少重复犯罪.
- 在类似的未来研究中,为优化参与者保留提供信息的策略.
主要方法:
- 进行了一项双盲,安慰剂控制的随机试验.
- 参与者是非常冲动的男人,有暴力犯罪的历史.
- 统计分析确定了消耗的预测因素,包括人口,社会和临床变量.
主要成果:
- 年龄,教育,社会支持,精神病史,以及先前监禁的长度显著预测了消耗.
- 参考来源和治疗分配没有显著预测消耗.
- 在转介来源子组中观察到到耗尽的中位时间的差异.
结论:
- 诸如年龄,教育,社会支持,精神病史和监禁史等因素预测了这一群体的退学情况.
- 这些发现与以前关于社区和犯罪者人口消耗的研究一致.
- 识别预测因素可以进行有针对性的干预,以改善临床试验的保留率,并为未来的研究提供信息.
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