在强力诱导过渡中出现de Gennes长度
Keerti Chauhan1, Garima Mishra2, Vimal Kishore1
1Department of Physics, Banaras Hindu University, Varanasi 221 005, India.
Physical review. E
|November 18, 2023
概括
这项研究模拟了DNA-蛋白相互作用,揭示了三种状态和相位图. 蛋白质展开取决于DNA链接尺寸和蛋白质稳定性,对复杂的生物系统有影响.
科学领域:
- 生物物理学的生物物理.
- 计算生物学 计算生物学
- 分子动力学分子动力学
背景情况:
- 了解DNA-蛋白相互作用对于分子生物学至关重要.
- 模拟这些复杂的系统需要准确的模型.
- 蛋白质展开和DNA破裂是关键的机械过程.
研究的目的:
- 研究DNA破裂和蛋白质在DNA-蛋白质结构中展开的蛋白质.
- 识别不同的形态状态及其依赖性.
- 探索DNA手柄大小和蛋白质稳定性对这些过程的影响.
主要方法:
- 兰格维恩对粗粒度DNA-蛋白质模型的动态模拟.
- 对力-延伸曲线的分析,以监测展开的路径.
- 基于系统参数构建相位图.
主要成果:
- 三种不同的状态的识别:拉链式DNA/崩的蛋白质,解压式DNA/拉伸式蛋白质和解压式DNA/崩的蛋白质.
- 一个阶段图,说明基于DNA手柄和蛋白质大小的状态转换.
- 证明蛋白质展开是由不太稳定的蛋白质的链接DNA大小控制的,并且受到更稳定的蛋白质的de Gennes长度的影响.
结论:
- 蛋白质展开的途径是复杂的,受到DNA机制和蛋白质稳定性的影响.
- 介质状态在蛋白质展开中起着至关重要的作用.
- 不同质的蛋白质系统可以表现出不同的展开路径,尽管类似的中间状态.
相关概念视频
Force and Potential Energy in One Dimension
5.4K
Force can be calculated from the expression for potential energy, which is a function of position. The component of a conservative force, in a particular direction, equals the negative of the derivative of the corresponding potential energy with respect to the displacement in that direction. For regions where potential energy changes rapidly with displacement, the work done and force is maximum. Also, when force is applied along the positive coordinate axis, the potential energy decreases with...
5.4K
Non-conservative Forces
7.9K
Non-conservative forces are dissipative forces such as friction or air resistance. These forces take energy away from a system as it progresses. Unlike conservative forces, non-conservative forces do not have potential energy associated with them. This is because the energy is lost to the system and cannot be turned into useful work later.
Also unlike their conservative counterparts, they are path-dependent; where the object starts and stops does matter. For example, a grinding wheel applies a...
Also unlike their conservative counterparts, they are path-dependent; where the object starts and stops does matter. For example, a grinding wheel applies a...
7.9K
Spin–Spin Coupling Constant: Overview
937
In bromoethane, the three methyl protons are coupled to the two methylene protons that are three bonds away. In accordance with the n+1 rule, the signal from the methyl protons is split into three peaks with 1:2:1 relative intensities. The methylene protons appear as a quartet, with the relative intensities of 1:3:3:1.
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must...
Qualitatively, any spin plus-half nucleus polarizes the spins of its electrons to the minus-half state. Consequently, the paired electron in the hydrogen–carbon bond must...
937
Gauss's Law
7.3K
If a closed surface does not have any charge inside where an electric field line can terminate, then the electric field line entering the surface at one point must necessarily exit at some other point of the surface. Therefore, if a closed surface does not have any charges inside the enclosed volume, then the electric flux through the surface is zero. What happens to the electric flux if there are some charges inside the enclosed volume? Gauss's law gives a quantitative answer to this question.
7.3K
Generation of Straight or Branched Actin Filaments
2.9K
The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
2.9K
Forces Acting on Chromosomes
3.3K
During mitosis, chromosome movements occur through the interplay of multiple piconewton level forces. In prometaphase, these forces help in chromosome assembly or congression at the equatorial plane, eventually leading to their alignment at the metaphase plate. The forces acting on the chromosomes are space and time-dependent; therefore, they vary with the position of the chromosomes as the cell progresses through mitosis.
Microtubules and motor proteins exert two types of forces on...
Microtubules and motor proteins exert two types of forces on...
3.3K


