提亚亚佐利丁-提安化合物的异构和过氧化植物毒性
Tetsuji Iida1, Satoshi Senoo1, Yukiharu Sato1
1Graduate School of Agricultural Science, Tamagawa University, Machida-shi, Tokyo 194, Japan.
Zeitschrift fur Naturforschung. C, Journal of biosciences
|November 18, 2023
概括
合成了新的蒂亚亚佐利丁-和三利丁-,并对植物毒性进行了测试. 蒂亚亚佐利丁-蒂昂体现出过氧化除草剂活性,而特里亚佐利丁-蒂昂体现出更强烈的植物毒性作用.
科学领域:
- 农业化学研究农业化学研究.
- 有机合成 有机合成
- 植物科学 植物科学
背景情况:
- 异环化合物的植物毒性是新型除草剂开发的活跃研究领域.
- 对于设计有效的农业化学品来说,了解亚利丁和三利丁衍生物的结构-活性关系至关重要.
研究的目的:
- 为了合成新型的5-arylimino-3,4-tetramethylene-1,3,4-thiadiazolidine-2-thiones和4-aryl-1,2-tetramethylene-1,2,4-triazolidine-3,5-dithiones. 这两种新型的烯酸和烯酸的合成.
- 评估这些合成化合物对各种植物和藻类物种的植物毒性活动.
- 研究合成化合物的除草剂作用模式和代谢稳定性.
主要方法:
- 合成了八种5-arylimino-3,4-tetramethylene-1,3,4-thiadiazolidine-2-thiones和八种4-aryl-1,2-tetramethylene-1,2,4-triazolidine-3,5-dithiones. 这两种物质的合成方法是:
- 使用沙瓦小米 (Echinochloa utilis) 和绿色微藻 (Scenedesmus acutus) 的植物毒性测定.
- 使用来自玉米 (Zea mays) 的proto-porphyrinogen-IX氧化酶的酶抑制测试和涉及谷氨S转移酶 (GST) 和谷氨 (GSH) 的代谢稳定性测试.
主要成果:
- 5-阿里利米诺-3,4-四四甲-1,3,4-提亚迪亚佐利丁-2-氨酸表现出显著的植物毒性活性,与过氧化除草剂一致.
- 在各种实验条件下,这些蒂亚亚佐利丁-提在各种实验条件下显示出有限的转化为三醇丁-提.
- 与其亚利丁-离子对应物相比,4-阿里尔-1,2-四甲-1,2,4-三利丁-3,5-二离子表现出更强烈的植物毒性活动.
结论:
- 合成的亚利丁-和亚利丁-是除草剂开发的潜在候选者.
- 独特的植物毒性特征表明这两类化合物的作用模式或代谢命运不同.
- 需要进一步研究这些化合物的结构-活性关系和特定标.
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