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肺癌与急性持续性脑缺血有关:一个基于人口的研究
Jonathan Naftali1, Rani Barnea1,2, Ruth Eliahou2,3
1Department of Neurology, Rabin Medical Center, Petach Tikva, Israel.
概括
大脑微发作 (CMI) 在肺癌患者中比其他癌症类型更为常见. 这些发现表明,CMI可能表明肺癌患者中风风险增加和认知问题.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 大脑微发作 (CMI) 是大脑缺血的一个常见症状,尽管在一般人群中很少见.
- 通过MRI-DWI仅可检测大约两周的CMI,并且与中风风险和认知障碍有关.
- 与其他癌症相比,肺癌 (LC) 与缺血性中风风险密切相关.
研究的目的:
- 调查诊断为肺癌 (LC) 的患者中CMI的检测率.
- 为了比较LC患者的CMI发病率与其他癌症 (乳腺癌,胰腺癌,结肠癌) 的患者.
主要方法:
- 使用克莱利特医疗服务记录超过500万名患者.
- 在诊断后5年内进行脑磁共振扫描的LC和非肺癌 (NLC) 已确定的成年患者.
- 审查了脑部MRI扫描的CMI和记录的心血管风险因素.
主要成果:
- 该研究分析了2056个LC患者扫描和1598个NLC患者扫描.
- 在3.5%的LC患者中发现了CMI,而在NLC患者中发现了1.4% (p < 0.01).
- 在多变量分析中,癌症类型是唯一与CMI发病率相关的重要因素,LC患者每年发病率较高 (2.5vs0.5每年).
结论:
- 在癌症患者中经常观察到CMI,特别是那些患有肺癌的人.
- CMI可能作为检测静音脑缺血,认知衰退和与癌症相关的中风 (CRS) 风险的潜在生物标志物.
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