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脊髓甲状腺癌的不断变化的治疗格局

Marta Laganà¹, Valentina Cremaschi¹, Andrea Alberti²

¹Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia at ASST Spedali Civili, 25123, Brescia, Italy.

Current treatment options in oncology

|November 18, 2023

概括

基因检测指导先进的甲状腺髓癌 (MTC) 治疗. 针对性治疗,如RET抑制剂和多氨酸激酶抑制剂 (mTKI) 提供基于特定基因突变的有效选择.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
药理学药理学是指药理学的学科.

背景情况:

晚期髓性甲状腺癌 (MTC) 治疗决策越来越多地以遗传特征为指导.
目前的治疗包括多氨酸激酶抑制剂 (mTKIs) 和选择性RET抑制剂,根据RET突变状态的有效性有所不同.

研究的目的:

概述针对晚期髓状甲状腺癌 (MTC) 的向治疗方法的现状和未来前景.
强调基因评估在指导MTC患者治疗选择中的重要性.

主要方法:

审查当前的临床指南和针对MTC的向治疗的新兴研究.
分析多氨酸激酶抑制剂 (mTKI) 和选择性RET抑制剂 (如普拉塞提尼布,塞尔珀卡提尼布) 的作用.

主要成果:

范德坦尼布和卡博桑提尼布是第一线的mTKIs,范德坦尼布仅限于RET突变的MTC.
选择性RET抑制剂如pralsetinib是首选用于常见/守门者RET突变的前期;selpercatinib是mTKI后的二线选择.
随后的线路可能涉及临床试验,其他mTKI,或免疫治疗高瘤突变负担MTC.

结论:

基因评估对于优化先进的MTC治疗策略至关重要.
建议采用使用mTKIs和选择性RET抑制剂的顺序方法,以突变状态为指导.
未来的方向包括下一代抑制剂和免疫疗法,以克服耐药性并改善结果.

关键词:

癌症癌症癌症癌症未来的选择未来的选择未来的选择甲状腺骨髓甲状腺是什么意思转移性MTC是转移性的多TKI 多TKI 多TKI 预处理的MTC RET 抑制剂的使用.在RET突变中.

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