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Updated: Jul 10, 2025

Detection and Isolation of Viable Mouse IL-17-Secreting T Cells
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Detection and Isolation of Viable Mouse IL-17-Secreting T Cells

Published on: December 18, 2008

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通过比较HD敲击猪和小鼠,揭示了IL-17的病理作用

Qingqing Jia1, Dazhang Bai2, Xiao Zheng1

  • 1Guangdong Key Laboratory of Non-human Primate Research, Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hongkong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou 510632, China.

Cell reports
|November 18, 2023
PubMed
概括

亨廷顿病 (HD) 猪模型显示,与小鼠不同,互白素-17 (IL-17) 信号传递增加. 这一途径加剧了质病理,表明IL-17是对HD的潜在治疗标.

关键词:
CP: 免疫学 免疫学科普:神经科学是什么意思亨廷顿病就是亨廷顿病.动物模型动物模型状腺病理学 状腺病理学介质蛋白-17 介质蛋白-17 介质蛋白-17.

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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