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家庭睡眠呼吸暂停测试:利益冲突和资金
Tanya Chen1, Melissa Lee1, Evelyn Constantin2
1Department of Otolaryngology-Head and Neck Surgery, University of Toronto, Toronto, Canada.
International journal of pediatric otorhinolaryngology
|November 18, 2023
概括
对于阻塞性睡眠呼吸暂停 (OSA) 的家庭睡眠呼吸暂停测试 (HSAT) 的一半研究缺乏资金或利益冲突 (COI) 披露. 行业资金与更高质量的研究相关,但COI报告仍然不一致.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 睡眠医学 睡眠医学
- 医学研究方法学 医学研究方法学
背景情况:
- 儿科耳鼻喉科医生使用家庭睡眠呼吸暂停测试 (HSAT) 来诊断阻塞性睡眠呼吸暂停 (OSA).
- HSAT文献的质量和透明度对于临床决策至关重要.
- 在此领域之前对资金和利益冲突 (COI) 的评估有限.
研究的目的:
- 评估20多年来HSAT出版物中融资和COI披露的普遍性.
- 检查资金来源,COI和HSAT研究质量的关系.
- 确定睡眠呼吸暂停研究透明度报告标准的趋势.
主要方法:
- 对Medline,Web of Science和Embase数据库进行了全面的文献审查.
- 从2000年1月到2021年12月的出版物使用牛津证据水平 (OLE) 作为质量指标进行了分析.
- 资金和COI声明是从手稿文本中逐字提取出来的.
主要成果:
- 在4257个已识别的文章中,有400个被纳入最终分析.
- 在过去五年 (2016-2021) 中,更高质量的研究 (LOE 1或2) 更普遍.
- 近一半 (43.0%) 的文章缺乏资金或COI声明,行业资金和研究质量之间存在正相关性.
结论:
- 在OSA的HSAT文献中,COI报告中存在显著的异质性,行业资金的普遍性很高.
- 需要达成共识,并更新医学期刊披露报告的指导方针.
- 需要提高透明度,以确保HSAT研究对儿科OSA诊断的可靠性.
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